如果您在 Windows 11/10 计算机上遇到Microsoft Defender 错误 0x80073b01^{(Microsoft Defender error 0x80073b01)}，您可以尝试我们将在本文中提供的解决方案以成功解决此问题。当您遇到此问题时，您将收到以下完整错误消息；

An error has occurred in the program during initialization. If this problem continues, please contact your system administrator.
Error code: 0x80073b01

Microsoft Defender 错误 0x80073b01

此错误代码 0x80073b01表示^{(error code 0x80073b01 )}Microsoft Defender与您计算机上的另一个安全程序之间存在干扰，或者有损坏的系统文件阻止它正常工作。这会导致Defender 应用程序无法初始化或加载^{(Defender application not being able to initialize or load)}。

ERROR_MUI_FILE_NOT_LOADED (0x80073b01)

Microsoft Defender 错误 0x80073b01

如果您遇到此问题，您可以尝试以下我们推荐的解决方案（不分先后顺序），看看是否有助于解决问题。

Disable/Uninstall 3rd方安全软件
检查 Windows Defender^{(Check Windows Defender)}服务状态
重新注册Windows Defender DLL文件
运行系统文件检查器。

让我们看一下关于列出的每个解决方案所涉及的过程的描述。

1 ] Disable/Uninstall 3rd方安全软件

要修复此错误，您必须使用其专用的防病毒删除工具^{(antivirus removal tool)}删除您可能已在 PC 上安装的任何第三方防病毒程序- 以删除与您的防病毒程序关联的所有文件。原因是，使用制造商提供的 AV 程序的自定义卸载工具（如果可用）更有效和更具侵入性，每当卸载防病毒软件时，因为存在注册表和依赖项，安装在传统控制面板^{(Control Panel)}卸载程序的操作系统深处(appwiz.cpl) 在大多数情况下可能会丢失。

2]检查Windows Defender^{(Check Windows Defender)}服务状态

运行services.msc^(servi)以打开服务管理器^{(open the Services Manager)}并确保以下服务^(Services)显示此状态：

Windows Defender Firewall – Automatic |开始
Windows Defender 高级威胁防护 - 手动^{(Defender Advanced Threat Protection – Manual)}
Microsoft Defender 防病毒网络检查服务 - 手动^{(Microsoft Defender Antivirus Network Inspection Service – Manual)}
Microsoft Defender 防病毒服务 - 手册^{(Microsoft Defender Antivirus Service – Manual)}。

3]重新注册Windows Defender DLL文件

0x800106ba

您需要重新注册Windows Defender DLL 文件。打开提升的命令提示符^{(Open an elevated Command Prompt)}窗口，键入“ regsvr32 文件名^{(regsvr32 file name)}”并按 Enter。

您必须重新注册这些 dll 文件中的每一个。因此，对于这些文件中的每一个，将“文件名^{(file name)}”替换为每个文件，一个接一个，然后按 Enter：

regsvr32 wuaueng.dll
regsvr32 wucltui.dll
regsvr32 softpub.dll
regsvr32 wintrust.dll
regsvr32 initpki.dll
regsvr32 wups.dll
regsvr32 wuweb.dll
regsvr32 atl.dll
regsvr32 mssip32.dll

重新启动^(Restart)，看看它是否对您有帮助。

如果您愿意，您可以下载并使用我们的便携式FixWin将^(FixWin)Microsoft Defender设置重置为默认值。

Microsoft Defender 错误 0x80073b01

您将在Additional Fixes > Quick Fixes > Reset Windows Defender Settings下找到该设置。

4]运行系统文件检查器

运行系统文件检查器，因为它将帮助您恢复任何损坏的系统文件。

Hope something here helps!

Fix Microsoft Defender error 0x80073b01 on Windows 11/10

If you’rе encountering Microsoft Defender error 0x80073b01 on your Windows 11/10 computer, you can try the solutions we will present in this post to successfully resolve this issue. When you encounter this issue, you’ll receive the following full error message;

An error has occurred in the program during initialization. If this problem continues, please contact your system administrator.
Error code: 0x80073b01

Microsoft Defender error 0x80073b01

This error code 0x80073b01 indicates that there is an interference between Microsoft Defender and another security program that you have on your computer, or there are corrupted system files that prevent it from working properly. This results in the Defender application not being able to initialize or load.

ERROR_MUI_FILE_NOT_LOADED (0x80073b01)

Microsoft Defender error 0x80073b01

If you’re faced with this issue, you can try our recommended solutions below in no particular order and see if that helps to resolve the issue.

Disable/Uninstall 3rd party security software
Check Windows Defender service status
Re-register Windows Defender DLL files
Run System File Checker.

Let’s take a look at the description of the process involved concerning each of the listed solutions.

1] Disable/Uninstall 3rd party security software

To fix this error, you’ll have to remove any third-party antivirus program you may have installed on your PC using its dedicated antivirus removal tool – to remove all files associated with your antivirus program. The reason is, it’s much more efficient and invasive to use the custom uninstall tools for the AV program from the manufacturer, if available, whenever uninstalling antivirus software, as there are registries and dependencies, installed deep within the OS which the traditional Control Panel uninstaller (appwiz.cpl) might miss in most cases.

2] Check Windows Defender service status

Run services.msc to open the Services Manager and ensure that the following Services show this status:

Windows Defender Firewall – Automatic | Started
Windows Defender Advanced Threat Protection – Manual
Microsoft Defender Antivirus Network Inspection Service – Manual
Microsoft Defender Antivirus Service – Manual.

3] Re-register Windows Defender DLL files

0x800106ba

You need to re-register the Windows Defender DLL files. Open an elevated Command Prompt window, type “regsvr32 file name” and hit Enter.

You have to re-register each of these dll files. So for each of these files, replace “file name” with each one of these, one after the other and hit Enter:

regsvr32 wuaueng.dll
regsvr32 wucltui.dll
regsvr32 softpub.dll
regsvr32 wintrust.dll
regsvr32 initpki.dll
regsvr32 wups.dll
regsvr32 wuweb.dll
regsvr32 atl.dll
regsvr32 mssip32.dll

Restart and see if it has helped you.

If you wish, you may download and use our portable FixWin to reset Microsoft Defender settings to default.

Microsoft Defender error 0x80073b01

You will find the setting under Additional Fixes > Quick Fixes > Reset Windows Defender Settings.

4] Run System File Checker

Run System File Checker as it will help you restore any corrupted system files.

Hope something here helps!

坤罗

About the author

拥有超过 10 年经验的发烧友工程师和音频产品专家。我专注于从头到尾创造优质的音乐扬声器和耳机。我是解决音频问题以及设计新扬声器和耳机系统的专家。我的经验不仅仅是制造好产品。我也热衷于帮助他人成为最好的自己，无论是通过教育还是社区服务。

修复 Windows 11/10 上的 Microsoft Defender 错误 0x80073b01